At 11,187 miles (18,003 km), Hong Kong to São Paulo is beyond the nonstop range of most airliners and is usually flown with a stop. Nonstop on a widebody it would take about 20h 15m.
São Paulo is 11 hours behind Hong Kong. You cross 11 time zones heading west. Westbound trips like this one are usually a little easier to adjust to, so plan for a day or two of jet lag.
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