The flight from Johannesburg (JNB) to Mexico City (MEX) takes about 16h 28m nonstop on a widebody airliner, covering 9,071 miles (14,598 km).
Mexico City is 8 hours behind Johannesburg. You cross 8 time zones heading west. Westbound trips like this one are usually a little easier to adjust to, so plan for a day or two of jet lag.
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