The flight from London (LHR) to San Diego (SAN) takes about 10h 48m nonstop on a widebody airliner, covering 5,472 miles (8,807 km).
San Diego is 8 hours behind London. You cross 8 time zones heading west. Westbound trips like this one are usually a little easier to adjust to, so plan for a day or two of jet lag.
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