The flight from Chicago (ORD) to Johannesburg (JNB) takes about 15h 36m nonstop on a widebody airliner, covering 8,711 miles (14,019 km).
Johannesburg is 7 hours ahead of Chicago. You cross 7 time zones heading east. Eastbound trips like this one tend to be harder to adjust to, so plan for a day or two of jet lag.
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