The flight from San Diego (SAN) to São Paulo (GRU) takes about 10h 56m nonstop on a widebody airliner, covering 6,061 miles (9,754 km).
São Paulo is 4 hours ahead of San Diego. You cross 4 time zones heading east. Eastbound trips like this one tend to be harder to adjust to, so plan for a day or two of jet lag.
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