The flight from San Francisco (SFO) to Rome (FCO) takes about 10h 30m nonstop on a widebody airliner, covering 6,250 miles (10,058 km).
Rome is 9 hours ahead of San Francisco. You cross 9 time zones heading east. Eastbound trips like this one tend to be harder to adjust to, so plan for a day or two of jet lag.
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