The flight from San Francisco (SFO) to São Paulo (GRU) takes about 11h 40m nonstop on a widebody airliner, covering 6,479 miles (10,427 km).
São Paulo is 4 hours ahead of San Francisco. You cross 4 time zones heading east. Eastbound trips like this one tend to be harder to adjust to, so plan for a day or two of jet lag.
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