The flight from São Paulo (GRU) to Istanbul (IST) takes about 11h 49m nonstop on a widebody airliner, covering 6,560 miles (10,557 km).
Istanbul is 6 hours ahead of São Paulo. You cross 6 time zones heading east. Eastbound trips like this one tend to be harder to adjust to, so plan for a day or two of jet lag.
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