The flight from Istanbul (IST) to São Paulo (GRU) takes about 11h 57m nonstop on a widebody airliner, covering 6,560 miles (10,557 km).
São Paulo is 6 hours behind Istanbul. You cross 6 time zones heading west. Westbound trips like this one are usually a little easier to adjust to, so plan for a day or two of jet lag.
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