At 10,180 miles (16,384 km), Johannesburg to Las Vegas is beyond the nonstop range of most airliners and is usually flown with a stop. Nonstop on a widebody it would take about 18h 27m.
Las Vegas is 9 hours behind Johannesburg. You cross 9 time zones heading west. Westbound trips like this one are usually a little easier to adjust to, so plan for a day or two of jet lag.
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