At 10,180 miles (16,384 km), Las Vegas to Johannesburg is beyond the nonstop range of most airliners and is usually flown with a stop. Nonstop on a widebody it would take about 18h 9m.
Johannesburg is 9 hours ahead of Las Vegas. You cross 9 time zones heading east. Eastbound trips like this one tend to be harder to adjust to, so plan for a day or two of jet lag.
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